The ability to efficiently and accurately determine genotypes is a keystone technology in modern genetics, crucial to studies ranging from clinical diagnostics, to genotype-phenotype association, to reconstruction of ancestry and the detection of selection. To date, high capacity, low cost genotyping has been largely achieved via "SNP chip" microarray-based …
De novo pathogenic SCN8A mutation identified by whole-genome sequencing of a family quartet affected by infantile epileptic encephalopathy and SUDEP Am J Hum Genet. 2012 Mar 9;90(3):502-10. doi: 10.1016/j.ajhg.2012.01.006. Epub …
Many existing de novo assembly tools for the next-generation sequencing reads adopt the de Bruijn graph approach (Butler et al., 2008; Chaisson et al., 2009; Li et al., 2010; Peng et al., 2010; Pevzner et al., 2001; Simpson et al., 2009; Zerbino and Birney, 2008) in which a vertex represents a unique length-k substring called k-mer and an edge ...
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In this article. Published: March 13, 2012. Version: 1.0 This bulletin summary lists security bulletins released for March 2012. With the release of the security bulletins for March 2012, this bulletin summary replaces the bulletin advance notification originally issued …
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Ghana Empire Wikipedia. The Ghana Empire (c. 300 until c. 1100), properly known as Wagadou (Ghana being the title of its ruler), was a West African empire located in the area of present-day southeastern Mauritania and western Maliplex societies based on trans-Saharan trade in salt and gold had existed in the region since ancient times, but the introduction of the camel to the …
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Estes tipos particulares de quadros são projetados para simplificar a modernização dos elevadores. Sua forma permite a instalação em locais estreitos
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Treated lesions will be up to 2 de novo native coronary artery lesions, each located in different major epicardial vessels, all with an angiographic maximal luminal diameter between 2.25 and 3.8 mm as estimated by online quantitative coronary angiography (QCA) and a lesion length of ≤48 mm. Clinical follow-up is planned at 30 and 180 days and ...
Proteins from an Unevolved Library of de novo Designed Sequences Bind a Range of Small Molecules Izhack Cherny,† Maria Korolev,† Angela N. Koehler,‡ and Michael H. Hecht*,† †Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States ‡Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, United States
Genomic architecture at the Incontinentia Pigmenti locus favours de novo pathological alleles through different mechanisms Hum Mol Genet. 2012 Mar 15;21(6):1260-71. doi: 10.1093/hmg/ddr556. Epub 2011 Nov 25. Authors Francesca Fusco 1 ...
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